So why haven’t you seen CBDA in most products? Because traditional processing uses heat, which destroys CBDA before it ever reaches you.
With our advanced extraction method, we preserve CBDA in its pure form — delivering a cold-pressed hemp juice that’s up to 99% bioavailable. A true first of its kind.
More potent than CBD at activating serotonin receptors¹
Reduction in nausea-like behavior in preclinical models¹
Higher absorption than CBD in preclinical models²
Heats or solvents used in Juicetiva's process
CBDA has been shown in preclinical studies to be up to 1,000 times more potent than CBD at activating the 5-HT1A serotonin receptor — a key player in regulating mood, nausea, and stress response.
Notably, CBDA was effective at significantly lower doses than CBD.¹
✓ Studied for its role in the body’s natural response to physical stressors
✓ Shown in early research to reduce nausea and vomiting in preclinical models¹
✓ Studied for its interaction with serotonin pathways and emotional regulation
Research shows CBDA may be more effective than CBD at inhibiting COX-2, an enzyme associated with inflammation and pain.
Studies indicate CBDA may be significantly more effective than CBD at activating 5-HT1A serotonin receptors, which help regulate nausea, anxiety, and mood.¹
CBDA has shown greater bioavailability than CBD, meaning the body can absorb and utilize it more effectively at lower doses.
Preliminary research suggests CBDA may have anticonvulsant properties that could help prevent seizures, potentially at lower doses than CBD.
Studies have shown CBDA may help inhibit the migration of aggressive breast cancer cells, suggesting potential applications in cancer treatment.
Recent research from Oregon State University found that CBDA may bind to the SARS-CoV-2 spike protein, potentially blocking the virus from entering cells.
The gut isn’t just for digestion; it’s home to trillions of microbes, immune cells, and neurotransmitter receptors that directly impact energy levels, mood, inflammation, and more.
When the gut is imbalanced, it can show up as fatigue, bloating, brain fog, low mood, or trouble sleeping — signs that the gut-brain connection may be under strain.
What we eat (or don’t eat) plays a major role in this system. Supporting gut health can help restore balance across the entire body, especially in areas related to stress resilience, mood regulation, and mental clarity.
Because JuiceTiva preserves CBDA in its raw, water-soluble plant matrix, it can be efficiently absorbed through the gut and enter systemic circulation. This natural form enhances bioavailability without the need for oils or synthetic carriers.
These receptors are densely located in the gut lining and play a key role in regulating mood, stress, inflammation, circadian rhythm, thermoregulation and more.
In fact, 90% of the body’s serotonin is produced in the gut, not the brain. This makes the enteric nervous system — often called the “second brain” — a major player in mood, resilience, and overall health.*
Serotonin produced in the gut travels along the vagus nerve to a central brain relay station called the nucleus tractus solitarius (NTS).
The NTS integrates the serotonin signals and sends them to higher regions of the brain, such as the dorsal raphe nucleus (DRN) and locus coeruleus (LC) — areas that regulate mood, stress, inflammation, and cognitive function.³
Supporting serotonin activity in the gut has been shown in scientific studies to enhance this communication pathway — potentially helping the body better adapt to stress, modulate inflammation, and maintain internal balance.
¹ Bolognini, D., Rock, E.M., Cluny, N.L., et al. (2013). Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. British Journal of Pharmacology, 168(6), 1456–1470.
² Wakshlag, J.J., Cital, S., Domitrovich, J., et al. (2020). Pharmacokinetics of cannabidiol, cannabidiolic acid, Δ9-tetrahydrocannabinol, and tetrahydrocannabinolic acid in canines. Frontiers in Veterinary Science, 7, Article 505.
³ Hwang, Y.K. & Oh, J.S. (2025). Interaction of the Vagus Nerve and Serotonin in the Gut–Brain Axis. International Journal of Molecular Sciences, 26(3), Article 1160.