The Science of Juicetiva™ Hemp Juice
More potent than CBD at activating serotonin receptors¹
Reduction in nausea-like behavior in preclinical models¹
Higher absorption than CBD in preclinical models²
Heats or solvents used in Juicetiva's process
CBDA (Cannabidiolic Acid) is a non-psychoactive cannabinoid found in raw, unheated cannabis plants. It is the acidic precursor to CBD and offers potential anti-inflammatory, anti-nausea, and other therapeutic properties. Research suggests CBDA may be more potent than CBD for certain applications.
CBDA has been shown to be up to 1000x more potent than CBD at activating the 5-HT1A serotonin receptor, which is deeply involved in regulating mood, nausea and stress response. 😮
Specifically, CBDA was effective at much lower doses compared to CBD.¹
The 5-HT1A Receptor
“The 5-HT1A receptor is one of the most studied serotonin receptors and is critically involved in regulating both mood and gastrointestinal homeostasis.”
“Targeting the 5-HT1A receptor has been shown to alleviate symptoms of depression, anxiety, and visceral pain, making it an ideal candidate for treating disorders of the gut–brain axis.”
“Dysfunction of 5-HT1A signaling contributes to inflammation, stress sensitivity, and emotional dysregulation.”
International Journal of Molecular Sciences, 2021
✓ Potential anti-inflammatory properties
✓ May help reduce nausea and vomiting
✓ Possible anxiety-reducing effects
✓ Natural compound found in raw hemp
CBDA has a unique molecular structure that includes a carboxylic acid group (COOH) attached to the molecule. This acid group is removed during decarboxylation, converting CBDA to CBD.
Serotonin produced in the gut doesn’t just affect digestion — it travels via the vagus nerve to a central brain relay station called the nucleus tractus solitarius (NTS).
The NTS then integrates the gut-derived serotonin signals and projects them to higher regions of the brain, such as the dorsal raphe nucleus (DRN) and locus coeruleus (LC) — areas that regulate mood, stress, inflammation, and cognitive function.³
Cannabinoids are naturally occurring compounds found in the Cannabis sativa plant.
They interact with the body's endocannabinoid system, which helps regulate various physiological processes including pain sensation, mood, and appetite.
Terpenes are aromatic compounds found in many plants, including hemp.
They give plants their distinctive smells and may offer various health benefits. In hemp, terpenes work synergistically with cannabinoids in what's known as the entourage effect.
Flavonoids are phytonutrients that give plants their vibrant colors and have powerful antioxidant properties.
In hemp, unique flavonoids called cannaflavins may contribute to the plant's anti-inflammatory effects.
Hemp contains an ideal ratio of omega-3 to omega-6 fatty acids, which are essential for human health. These fatty acids support heart health, reduce inflammation, and contribute to brain function.
Chlorophyll is the green pigment in plants responsible for photosynthesis.
In hemp, chlorophyll provides detoxifying properties, supports immune function, and may help with inflammation and wound healing.
Research shows these significant health benefits of CBDA
Research shows CBDA may be more effective than CBD at inhibiting COX-2, an enzyme associated with inflammation and pain.
Studies indicate CBDA may be significantly more effective than CBD at activating 5-HT1A serotonin receptors, which help regulate nausea, anxiety, and mood.
CBDA has shown greater bioavailability than CBD, meaning the body can absorb and utilize it more effectively at lower doses.
Preliminary research suggests CBDA may have anticonvulsant properties that could help prevent seizures, potentially at lower doses than CBD.
Studies have shown CBDA may help inhibit the migration of aggressive breast cancer cells, suggesting potential applications in cancer treatment.
Recent research from Oregon State University found that CBDA may bind to the SARS-CoV-2 spike protein, potentially blocking the virus from entering cells.
Discover the science-backed benefits of raw CBDA and why it's revolutionizing the wellness industry.
Raw CBDA offers superior absorption compared to CBD, making it more effective at lower doses.
CBDA (cannabidiolic acid) is more bioavailable than CBD because it interacts differently with our endocannabinoid system. Research shows that CBDA can be absorbed up to 11 times more efficiently than CBD, allowing for smaller doses to achieve therapeutic effects.
[Citation]Anderson, L. L., et al. (2021). "Acidic Precursor Phytocannabinoids Display Enhanced Bioavailability Compared to Neutral Phytocannabinoids." Journal of Natural Products, 84(4), 1248-1259.
CBDA demonstrates potent anti-inflammatory effects through COX-2 enzyme inhibition.
CBDA has been shown to selectively inhibit cyclooxygenase-2 (COX-2), an enzyme associated with inflammation and pain. This mechanism is similar to how non-steroidal anti-inflammatory drugs (NSAIDs) work, but with potentially fewer side effects. This makes CBDA a promising natural alternative for inflammatory conditions.
[Citation]Takeda, S., et al. (2008). "Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis." Drug Metabolism and Disposition, 36(9), 1917-1921.
Research suggests CBDA may be more effective than CBD at reducing anxiety and stress responses.
CBDA has been found to interact with serotonin receptors (5-HT1A) with greater potency than CBD. This interaction is believed to play a key role in regulating anxiety, stress, and mood. Studies indicate that CBDA may require significantly lower doses than CBD to produce anxiolytic (anti-anxiety) effects.
[Citation]Rock, E. M., et al. (2018). "Effect of cannabidiolic acid and ∆9-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain." Psychopharmacology, 235(11), 3259-3271.
CBDA shows remarkable effectiveness in reducing nausea and vomiting, even at very low doses.
CBDA has demonstrated powerful antiemetic (anti-nausea) properties in scientific studies. It appears to be particularly effective at reducing anticipatory nausea, a condition that doesn't respond well to conventional treatments. Research suggests CBDA may be effective at doses hundreds of times lower than required with CBD.
[Citation]Rock, E. M., et al. (2013). "Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation." British Journal of Pharmacology, 168(6), 1456-1470.
Raw CBDA works synergistically with other plant compounds to enhance therapeutic benefits.
The entourage effect describes how cannabinoids, terpenes, and other plant compounds work together to produce enhanced therapeutic effects compared to isolated compounds. Raw, unheated cannabis contains a full spectrum of cannabinoid acids, terpenes, and flavonoids that work synergistically. This natural combination may provide greater benefits than isolated CBD.
[Citation]Russo, E. B. (2019). "The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No 'Strain,' No Gain." Frontiers in Plant Science, 9, 1969.
CBDA shows promising neuroprotective properties that may benefit brain health and cognitive function.
Emerging research suggests CBDA may have neuroprotective properties that could help maintain brain health. Its anti-inflammatory and antioxidant properties may protect neurons from damage and degeneration. Some studies indicate potential benefits for conditions involving neuroinflammation and oxidative stress in the brain.
[Citation]Formato, M., et al. (2020). "The Effect of Cannabidiolic Acid (CBDA) on Learning and Memory in Healthy and Amyloid β-Injected Mice." Biomolecules, 10(9), 1328.
¹ Bolognini, D., Rock, E.M., Cluny, N.L., et al. (2013). Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. British Journal of Pharmacology, 168(6), 1456–1470.
² Wakshlag, J.J., Cital, S., Domitrovich, J., et al. (2020). Pharmacokinetics of cannabidiol, cannabidiolic acid, Δ9-tetrahydrocannabinol, and tetrahydrocannabinolic acid in canines. Frontiers in Veterinary Science, 7, Article 505.
³ Hwang, Y.K. & Oh, J.S. (2025). Interaction of the Vagus Nerve and Serotonin in the Gut–Brain Axis. International Journal of Molecular Sciences, 26(3), Article 1160.